{"id":52935,"date":"2025-07-08T16:51:42","date_gmt":"2025-07-08T14:51:42","guid":{"rendered":"https:\/\/quimark.com\/?p=52935"},"modified":"2025-07-17T13:22:11","modified_gmt":"2025-07-17T11:22:11","slug":"divitum-tka","status":"publish","type":"post","link":"https:\/\/quimark.com\/en\/divitum-tka\/","title":{"rendered":"DiviTum\u00ae TKa"},"content":{"rendered":"

[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d background_color=\u201d#002855\u2033 custom_padding=\u201d6px||6px||true|false\u201d global_colors_info=\u201d{}\u201d][et_pb_row _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d custom_padding=\u201d15px||9px||false|false\u201d collapsed=\u201doff\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][et_pb_text _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d text_font=\u201d|700|||||||\u201d text_text_color=\u201d#FFFFFF\u201d text_font_size=\u201d46px\u201d text_line_height=\u201d1.2em\u201d header_font=\u201d|700|||||||\u201d header_text_color=\u201d#FFFFFF\u201d header_font_size=\u201d46px\u201d header_line_height=\u201d1.2em\u201d background_enable_color=\u201doff\u201d text_orientation=\u201dcenter\u201d width=\u201d66%\u201d module_alignment=\u201dcenter\u201d custom_padding=\u201d42px||18px||false|false\u201d header_font_tablet=\u201d|700|||||||\u201d header_font_phone=\u201d|700|||||||\u201d header_font_last_edited=\u201don|phone\u201d header_font_size_tablet=\u201d46px\u201d header_font_size_phone=\u201d22px\u201d header_font_size_last_edited=\u201don|phone\u201d global_colors_info=\u201d{}\u201d]<\/p>\n

DiviTum\u00ae<\/span>\u00a0<\/span>TKa<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d custom_padding=\u201d10px||4px|||\u201d global_colors_info=\u201d{}\u201d][et_pb_row column_structure=\u201d1_4,3_4\u2033 _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d18px|auto||auto||\u201d custom_padding=\u201d|51px||||\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][et_pb_image src=\u201dhttps:\/\/quimark.com\/wp-content\/uploads\/2025\/07\/woman-blue-glasses-gold-sweater-scaled-1-500\u00d7281-1.jpeg\u201d title_text=\u201dwoman-blue-glasses-gold-sweater-scaled-1-500\u00d7281\u2033 force_fullwidth=\u201don\u201d _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][et_pb_image src=\u201dhttps:\/\/quimark.com\/wp-content\/uploads\/2025\/07\/site-logo-divitum.png\u201d title_text=\u201dsite-logo-divitum\u201d url=\u201dhttps:\/\/www.canhelpgenomics.com\/index\u201d url_new_window=\u201don\u201d _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d width=\u201d100%\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][\/et_pb_column][et_pb_column type=\u201d3_4\u2033 _builder_version=\u201d4.25.1\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][et_pb_text _builder_version=\u201d4.27.0\u2033 text_font=\u201d|600|||||||\u201d text_text_color=\u201d#c8102e\u201d text_font_size=\u201d22px\u201d text_line_height=\u201d1.2em\u201d custom_margin=\u201d||-1px|||\u201d custom_padding=\u201d||17px|||\u201d global_colors_info=\u201d{}\u201d]<\/p>\n

Quantitative Test for the Evaluation of Metastatic Tumor Proliferation<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=\u201d4.27.0\u2033 text_font=\u201d||||||||\u201d text_text_color=\u201d#000000\u2033 text_font_size=\u201d17px\u201d text_line_height=\u201d1.8em\u201d ol_line_height=\u201d1.8em\u201d header_3_font=\u201d|700|||||||\u201d header_3_font_size=\u201d23px\u201d header_3_line_height=\u201d1.5em\u201d custom_margin=\u201d-10px|||||\u201d custom_padding=\u201d3px|||||\u201d global_colors_info=\u201d{}\u201d]<\/p>\n

<\/h3>\n

Divitum TKa Utilities<\/h3>\n

The DiviTum\u00ae TKa test measures the activity of thymidine kinase 1 (TK1) in the blood, an enzyme released by proliferating tumor cells. The result is a DiviTum activity score, which provides valuable information about the proliferative status of the patient's disease. It is particularly useful for early prognosis and assessing treatment efficacy in patients with HR+ metastatic postmenopausal breast cancer.<\/p>\n

<\/p>\n

Divitum TKa is a CE IVD certified kit<\/h3>\n

DiviTum\u00ae TKa is a certified in vitro diagnostic medical device (CE IVD).
The test is performed on serum obtained from blood samples and is based on a multi-step endpoint ELISA technology, which analyzes a cascade of enzymatic reactions to quantify the level of thymidine kinase activity.<\/p>\n

<\/h3>\n

Sensitivity and specificity<\/h3>\n

Clinical studies demonstrate that a patient with a negative test result has a 97% chance of not experiencing tumor progression in the next 30 days.
The reduced probability of progression within 30 or 60 days of testing suggests the use of DiviTum TKa as a complementary tool to imaging, especially in the periods between one radiological examination and the next.<\/p>\n

 <\/p>\n

Procedure<\/h3>\n

The procedure for performing the Divitum TKa test involves the following steps:<\/p>\n

\"\"<\/p>\n

The data obtained from the ELISA test are processed directly by the microplate reader, which provides the final Divitum data.<\/p>\n

 <\/p>\n

The result of Divitum TKa<\/h3>\n

The DiviTum\u00ae TKa test can provide clinicians with insights into changes in tumor cell proliferation in response to therapy, months earlier than conventional imaging. It is particularly useful in cases of non-measurable disease, which may be missed by traditional radiological techniques. Even in the presence of measurable disease, TKa activity analysis can complement imaging, helping clarify diagnostic questions and improving the overall accuracy of the assessment.<\/p>\n

 <\/p>\n

Bibliography<\/h3>\n

Paoletti C, et al. Clin Cancer Res. 2021 Nov 15;27(22):6115-6123
Bergqvist M, et al. Biomarkers, 2023, DOI: 10.1080\/1354750X.2023.2168063
Bitter EE, et al. Cell Biosci. 2020;10(1):138.
Larsson AM, et al. Sci Rep. 2020;10(1):4484
Gaughran G, et al, Breast Cancer Management, 2023 https:\/\/doi.org\/10.2217
Krishnamurthy J, et al. npi Breast Cancer 8, 35 (2022)<\/p>\n

 <\/p>\n

For more information click HERE<\/a><\/h3>\n

\"\"<\/a><\/p>\n

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DiviTum\u00ae TKa Quantitative Test for the Assessment of Metastatic Tumor Proliferation. DiviTum TKa Uses: The DiviTum\u00ae TKa test measures the activity of thymidine kinase 1 (TK1) in the blood, an enzyme released by proliferating tumor cells. The result is a DiviTum activity score, which provides valuable information about the proliferative status of the patient's disease. It is [\u2026]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[13],"tags":[],"class_list":["post-52935","post","type-post","status-publish","format-standard","hentry","category-prodotti"],"yoast_head":"\nDiviTum\u00ae TKa - eurobiodid - Oncologia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/quimark.com\/en\/divitum-tka\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DiviTum\u00ae TKa - eurobiodid - Oncologia\" \/>\n<meta property=\"og:description\" content=\"DiviTum\u00ae\u00a0TKaTest Quantitativo per la Valutazione della Proliferazione Tumorale Metastatica Utilit\u00e0 di Divitum TKa Il test DiviTum\u00ae\u202fTKa misura l\u2019attivit\u00e0 della timidina chinasi 1 (TK1) nel sangue, un enzima rilasciato dalle cellule tumorali in fase di proliferazione. Il risultato \u00e8 un punteggio di attivit\u00e0 DiviTum, che fornisce indicazioni preziose sullo stato proliferativo della malattia della paziente. \u00c8 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/quimark.com\/en\/divitum-tka\/\" \/>\n<meta property=\"og:site_name\" content=\"eurobiodid - Oncologia\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-08T14:51:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-17T11:22:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/divitum.com\/wp-content\/uploads\/2023\/06\/animering-new-9.0-final-1.gif\" \/>\n<meta name=\"author\" content=\"info@quimark.com\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"info@quimark.com\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/quimark.com\/divitum-tka\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/quimark.com\/divitum-tka\/\"},\"author\":{\"name\":\"info@quimark.com\",\"@id\":\"https:\/\/quimark.com\/#\/schema\/person\/f5d3b2d1634ec8bff68b3d29dfe38899\"},\"headline\":\"DiviTum\u00ae TKa\",\"datePublished\":\"2025-07-08T14:51:42+00:00\",\"dateModified\":\"2025-07-17T11:22:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/quimark.com\/divitum-tka\/\"},\"wordCount\":2269,\"publisher\":{\"@id\":\"https:\/\/quimark.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/quimark.com\/divitum-tka\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/divitum.com\/wp-content\/uploads\/2023\/06\/animering-new-9.0-final-1.gif\",\"articleSection\":[\"Prodotti\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/quimark.com\/divitum-tka\/\",\"url\":\"https:\/\/quimark.com\/divitum-tka\/\",\"name\":\"DiviTum\u00ae TKa - 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