{"id":52857,"date":"2025-03-21T17:26:36","date_gmt":"2025-03-21T16:26:36","guid":{"rendered":"https:\/\/quimark.com\/?p=52857"},"modified":"2025-04-15T13:59:26","modified_gmt":"2025-04-15T11:59:26","slug":"canhelp-origin-2","status":"publish","type":"post","link":"https:\/\/quimark.com\/en\/canhelp-origin-2\/","title":{"rendered":"Canhelp\u00ae Origin"},"content":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d background_color=\u201d#002855\u2033 custom_padding=\u201d6px||6px||true|false\u201d global_colors_info=\u201d{}\u201d][et_pb_row _builder_version=\u201d4.24 .2\u2033 _module_preset=\u201ddefault\u201d custom_padding=\u201d15px||9px||false|false\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d {}\u201d][et_pb_text _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d text_font=\u201d|700|||||||\u201d text_text_color=\u201d#FFFFFF\u201d text_font_size=\u201d46px\u201d text_line_height=\u201d1.2em\u201d header_font=\u201d|700|||||||\u201d header_text_color=\u201d#FFFFFF\u201d header_font_size=\u201d46px\u201d header_line_height=\u201d1.2em\u201d background_enable_color=\u201doff\u201d text_orientation=\u201dcenter\u201d width=\u201d66%\u201d module_alignment=\u201dcenter\u201d custom_padding=\u201d42px||18px||false|false\u201d header_font_tablet =\u201d|700|||||||\u201d header_font_phone=\u201d|700|||||||\u201d header_font_last_edited=\u201don|phone\u201d header_font_size_tablet=\u201d46px\u201d header_font_size_phone=\u201d22px\u201d header_font_size_last_edited=\u201don|phone\u201d global_colors_info=\u201d{}\u201d]<\/p>\n<h1>Canhelp\u00ae \u2013 Origin<\/h1>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d custom_padding=\u201d10px||4px|||\u201d global_colors_info=\u201d{}\u201d][et_pb_row column_structure=\u201d1_4,3_4\u2033 _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d18px|auto||auto||\u201d custom_padding=\u201d|51px||||\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][et_pb_image src=\u201dhttps:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Canhelp-Origin.jpeg\u201d title_text=\u201dCanhelp-Origin\u201d force_fullwidth=\u201don\u201d _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][et_pb_image src=\u201dhttps:\/\/quimark.com\/wp-content\/uploads\/2025\/01\/\u82f1\u6587logo.png\u201d title_text=\u201d\u82f1\u6587logo\u201d url=\u201dhttps:\/\/www.canhelpgenomics.com\/index\u201d url_new_window=\u201don\u201d _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d width=\u201d100%\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][\/et_pb_column][et_pb_column type=\u201d3_4\u2033 _builder_version=\u201d4.25.1\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][et_pb_text _builder_version=\u201d4.27.0\u2033 text_font=\u201d|600|||||||\u201d text_text_color=\u201d#c8102e\u201d text_font_size=\u201d22px\u201d text_line_height=\u201d1.2em\u201d custom_margin=\u201d||-1px|||\u201d custom_padding=\u201d||17px|||\u201d global_colors_info=\u201d{}\u201d]<\/p>\n<p>Diagnostic Test for Identifying the Origin of the Tumor<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u201d4.27.0\u2033 text_font=\u201d||||||||\u201d text_text_color=\u201d#000000\u2033 text_font_size=\u201d17px\u201d text_line_height=\u201d1.8em\u201d ol_line_height=\u201d1.8em\u201d header_3_font=\u201d|700|||||||\u201d header_3_font_size=\u201d23px\u201d header_3_line_height=\u201d1.5em\u201d custom_margin=\u201d-10px|||||\u201d hover_enabled=\u201d0\u2033 global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n<h3><\/h3>\n<h3>Canhelp-Origin Utility<\/h3>\n<p>Canhelp-Origin is a molecular test used on FFPE tumor tissue samples to identify the primary site of a metastatic tumor, particularly useful in poorly differentiated or undifferentiated tumors, for which the origin is unknown, such as in tumors classified as CUP (Carcinoma of Unknown Primary).<br \/>Canhelp-Origin uses quantitative RT-PCR technology and has been clinically validated, with overall accuracy superior to 90% in identifying primary sites of metastatic tumors.<br \/>The test evaluates the expression of 90 genes specific to 21 tumors and covers over 95% of solid tumors by incidence worldwide.<\/p>\n<p><a href=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Canhelp-Origin-Brochure-1.jpeg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Canhelp-Origin-Brochure-1.jpeg\" width=\"936\" height=\"926\" alt=\"\" class=\"wp-image-52868 alignnone size-full\" style=\"display: block; margin-left: auto; margin-right: auto;\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Canhelp-Origin-Brochure-1.jpeg 936w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Canhelp-Origin-Brochure-1-480x475.jpeg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 936px, 100vw\" \/><\/a><\/p>\n<h3>Intended uses<\/h3>\n<p>For the molecular pathologist, the use of the kit is indicated in the following cases:<\/p>\n<ul>\n<li>the tumor is <span style=\"text-decoration: underline;\">poorly differentiated or undifferentiated<\/span><\/li>\n<li>the sample is of <span style=\"text-decoration: underline;\">compact size<\/span> and this limits the diagnostic process<\/li>\n<li>the <span style=\"text-decoration: underline;\">IHC results are inconclusive<\/span> or contradict previous results<\/li>\n<li>And <span style=\"text-decoration: underline;\">impossible to diagnose<\/span> differentially two or more types of tumors<\/li>\n<\/ul>\n<p>For the oncologist, the kit is used when:<\/p>\n<ul>\n<li>the patient has a history of <span style=\"text-decoration: underline;\">multiple tumors<\/span><\/li>\n<li>we are in the presence of <span style=\"text-decoration: underline;\">atypical metastatic sites<\/span><\/li>\n<li>the <span style=\"text-decoration: underline;\">diagnosis<\/span> clinical and pathological are <span style=\"text-decoration: underline;\">discordant<\/span><\/li>\n<li>there is a <span style=\"text-decoration: underline;\">doubt about the diagnosis<\/span> after a therapeutic failure<\/li>\n<\/ul>\n<h3><\/h3>\n<h3>Canhelp-Origin is a CE IVD certified kit<\/h3>\n<p>Canhelp-Origin is performed on FFPE tumor tissue samples (from poorly differentiated, undifferentiated and metastatic tumors) directly in the laboratory.<\/p>\n<p>The test analyzes the expression pattern of 90 genes from RNA extracted from FFPE samples via RT-qPCR and calculates similarity scores for each of the 21 tumor types investigated.<\/p>\n<p>Each Canhelp-Origin kit contains materials and reagents for 10 tests.<\/p>\n<h3><\/h3>\n<h3>Sensitivity and specificity<\/h3>\n<p>Clinical studies have shown a high sensitivity and specificity of the test, as well as its efficacy in guiding treatment and improving survival in patients with carcinoma of unknown origin.<\/p>\n<p><a href=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Immagine1.png\"><\/a><a href=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-24-115149.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-24-115149.png\" width=\"728\" height=\"478\" alt=\"\" class=\"wp-image-52871 alignnone size-full\" style=\"display: block; margin-left: auto; margin-right: auto;\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-24-115149.png 728w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-24-115149-480x315.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 728px, 100vw\" \/><\/a><\/p>\n<h3>Procedure<\/h3>\n<p>The procedure for running the Canhelp-Origin test involves the following steps:<\/p>\n<p><a href=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/04\/Origin-procedimento.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/04\/Origin-procedimento.jpg\" width=\"2480\" height=\"1129\" alt=\"\" class=\"wp-image-52917 aligncenter size-full\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/04\/Origin-procedimento.jpg 2480w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/04\/Origin-procedimento-1280x583.jpg 1280w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/04\/Origin-procedimento-980x446.jpg 980w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/04\/Origin-procedimento-480x219.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 2480px, 100vw\" \/><\/a><\/p>\n<p>The data obtained from the PCR are analyzed by the <strong><em>Canhelp\u2122-Origin Software (CE-IVD)<\/em><\/strong> to determine the similarity between the sample&#039;s gene profile and the profiles of 21 tumors.<\/p>\n<h3>The Canhelp-Origin report<\/h3>\n<p>The report provides a ranking of the 21 most common tumor types, indicating for each a similarity score that represents the probability that the tumor originates from that specific tissue. In the example below, the highest score is associated with breast cancer, which suggests that the tumor may originate in the breast.<br \/>For each tumor type analyzed, the report provides a similarity score ranging from 0 to 100. The total sum of the scores is 100, and a tumor type with a score higher than 45.3 is the most likely site of origin of the tumor.<\/p>\n<p><a href=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Immagine2.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Immagine2.jpg\" width=\"642\" height=\"481\" alt=\"\" class=\"wp-image-52874 alignnone size-full\" style=\"display: block; margin-left: auto; margin-right: auto;\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Immagine2.jpg 642w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Immagine2-480x360.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 642px, 100vw\" \/><\/a><\/p>\n<h3>Bibliography<\/h3>\n<p>Canhelp-Origin has been validated on more than 3000 cancer patients and more than 18 scientific articles have been published.<\/p>\n<p><a href=\"https:\/\/www.thelancet.com\/journals\/lanonc\/article\/PIIS1470-2045(24)00313-9\/abstract\" target=\"_blank\" rel=\"noopener\">Liu, Xin et al., The Lancet Oncology, 2024<\/a><\/p>\n<p>&nbsp;<\/p>\n<h3>For more information click <a href=\"https:\/\/www.canhelpgenomics.com\/products_show?id=1\" target=\"_blank\" rel=\"noopener\">HERE<\/a><\/h3>\n<p><a href=\"https:\/\/www.canhelpgenomics.com\/products_show?id=1\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2024\/07\/doctor-with-laptop-1024x572.jpg\" width=\"1024\" height=\"572\" alt=\"\" class=\"wp-image-52321 alignnone size-large\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2024\/07\/doctor-with-laptop-980x547.jpg 980w, https:\/\/quimark.com\/wp-content\/uploads\/2024\/07\/doctor-with-laptop-480x268.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 admin_label=\u201ds\u201d _builder_version=\u201d4.27.0\u2033 background_color=\u201d#002855\u2033 custom_margin=\u201d||-28px|||\u201d custom_padding=\u201d0px||36px||false|false\u201d box_shadow_style=\u201dpreset7\u2033 box_shadow_horizontal=\u201d0px\u201d box_shadow_vertical=\u201d100px\u201d box_shadow_color=\u201d#ffffff\u201d global_module=\u201d51463\u2033 saved_tabs=\u201dall\u201d global_colors_info=\u201d{}\u201d][et_pb_row column_structure=\u201d1_3,1_3,1_3\u2033 padding_top_bottom_link_1=\u201dtrue\u201d padding_left_right_link_1=\u201dtrue\u201d _builder_version=\u201d4.27.0\u2033 custom_padding=\u201d0px||0px||true\u201d animation_direction=\u201dbottom\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_3\u2033 _builder_version=\u201d4.25.2\u2033 background_color=\u201d#c8102e\u201d 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