{"id":52820,"date":"2025-01-20T12:50:55","date_gmt":"2025-01-20T11:50:55","guid":{"rendered":"https:\/\/quimark.com\/?p=52820"},"modified":"2025-07-17T13:48:00","modified_gmt":"2025-07-17T11:48:00","slug":"canhelp-uca-ce-ivd","status":"publish","type":"post","link":"https:\/\/quimark.com\/en\/canhelp-uca-ce-ivd\/","title":{"rendered":"Canhelp\u00ae-UCa"},"content":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d background_color=\u201d#002855\u2033 custom_padding=\u201d6px||6px||true|false\u201d global_colors_info=\u201d{}\u201d][et_pb_row _builder_version=\u201d4.24 .2\u2033 _module_preset=\u201ddefault\u201d custom_padding=\u201d15px||9px||false|false\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d {}\u201d][et_pb_text _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d text_font=\u201d|700|||||||\u201d text_text_color=\u201d#FFFFFF\u201d text_font_size=\u201d46px\u201d text_line_height=\u201d1.2em\u201d header_font=\u201d|700|||||||\u201d header_text_color=\u201d#FFFFFF\u201d header_font_size=\u201d46px\u201d header_line_height=\u201d1.2em\u201d background_enable_color=\u201doff\u201d text_orientation=\u201dcenter\u201d width=\u201d66%\u201d module_alignment=\u201dcenter\u201d custom_padding=\u201d42px||18px||false|false\u201d header_font_tablet =\u201d|700|||||||\u201d header_font_phone=\u201d|700|||||||\u201d header_font_last_edited=\u201don|phone\u201d header_font_size_tablet=\u201d46px\u201d header_font_size_phone=\u201d22px\u201d header_font_size_last_edited=\u201don|phone\u201d global_colors_info=\u201d{}\u201d]<\/p>\n<h1>Canhelp\u00ae-UCa CE-IVD<\/h1>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d4.24.2\u2033 _module_preset=\u201ddefault\u201d custom_padding=\u201d10px||4px|||\u201d global_colors_info=\u201d{}\u201d][et_pb_row column_structure=\u201d1_4,3_4\u2033 _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d18px|auto||auto||\u201d custom_padding=\u201d|51px||||\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][et_pb_image src=\u201dhttps:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/a1.png\u201d title_text=\u201da1\u2033 force_fullwidth=\u201don\u201d _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][et_pb_image src=\u201dhttps:\/\/quimark.com\/wp-content\/uploads\/2025\/01\/\u82f1\u6587logo.png\u201d title_text=\u201d\u82f1\u6587logo\u201d url=\u201dhttps:\/\/www.canhelpgenomics.com\/index\u201d url_new_window=\u201don\u201d _builder_version=\u201d4.27.0\u2033 _module_preset=\u201ddefault\u201d width=\u201d100%\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][\/et_pb_column][et_pb_column type=\u201d3_4\u2033 _builder_version=\u201d4.25.1\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][et_pb_text _builder_version=\u201d4.27.0\u2033 text_font=\u201d|600|||||||\u201d text_text_color=\u201d#c8102e\u201d text_font_size=\u201d22px\u201d text_line_height=\u201d1.2em\u201d custom_margin=\u201d||-1px|||\u201d custom_padding=\u201d||17px|||\u201d global_colors_info=\u201d{}\u201d]<\/p>\n<p>Diagnostic Test for Urothelial Cancer Detection<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u201d4.27.0\u2033 text_font=\u201d||||||||\u201d text_text_color=\u201d#000000\u2033 text_font_size=\u201d17px\u201d text_line_height=\u201d1.8em\u201d ol_line_height=\u201d1.8em\u201d header_3_font=\u201d|700|||||||\u201d header_3_font_size=\u201d23px\u201d header_3_line_height=\u201d1.5em\u201d custom_margin=\u201d-10px|||||\u201d global_colors_info=\u201d{}\u201d]<\/p>\n<h3><\/h3>\n<h3>Canhelp-UCa Utility<\/h3>\n<p>Current guidelines for urothelial carcinoma support a diagnostic approach based on cystoscopy combined with sample urinary cytology.<\/p>\n<p>There <strong>cystoscopy<\/strong> It&#039;s a procedure <strong>invasive<\/strong>, <strong>uncomfortable<\/strong>, which carries a high cost and risks of infection and trauma, but which remains the gold standard for the diagnosis of urinary tumors.<\/p>\n<p>To limit its use, Canhelp Genomics has developed <strong>Canhelp-UCa<\/strong>, a diagnostic test with <strong>high sensitivity and specificity<\/strong> that improves bladder cancer detection rates. These features make Canhelp-UCa a useful tool to reduce the use of cystoscopy, offering a more accessible and less invasive screening method.<\/p>\n<p>Canhelp-UCa is a multigene diagnostic test that can aid in the diagnosis and monitoring of urothelial tumors.<br \/>The test evaluates, starting from urine samples, the expression of 8 genes (<em>CA9, CCL18, ERBB2, IGF2, MMP12, PPP1R14D, SGK2 and SWINGN<\/em>) in an RT-PCR assay. The data is processed by software that uses artificial intelligence.<\/p>\n<p>&nbsp;<\/p>\n<h3>Using Canhelp-UCa brings several benefits.<\/h3>\n<p>Benefits for the patient:<\/p>\n<ul>\n<li>The test is non-invasive and painless compared to cystoscopy<\/li>\n<li>increases the detection rate of bladder cancer in early and low-grade stages, improving prognosis<\/li>\n<li>reduces anxiety for patients who require frequent testing<\/li>\n<\/ul>\n<p>Benefits for the healthcare facility:<\/p>\n<ul>\n<li>The test helps doctors obtain additional information for more accurate diagnosis and treatment<\/li>\n<li>increases the willingness of patients to undergo frequent examinations to monitor recurrences after surgery<\/li>\n<li>The test is easy to implement<\/li>\n<\/ul>\n<p><a href=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-28-111139.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-28-111139.png\" width=\"696\" height=\"376\" alt=\"\" class=\"wp-image-52897 aligncenter size-full\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-28-111139.png 696w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-28-111139-480x259.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 696px, 100vw\" \/><\/a><\/p>\n<h3>Canhelp-UCa is a CE IVD certified kit<\/h3>\n<p>Canhelp-UCa is performed directly in the laboratory on 50 ml of the first urine of the day.<\/p>\n<p>The test analyzes the expression of 8 genes from the RNA extracted from the urine sample by RT-PCR and calculates the score that classifies the result as positive or negative for the presence of the tumor. The Canhelp-UCa test has a high specificity and sensitivity for all tumors, regardless of stage, with an accuracy of 93.4%, a sensitivity of 92.3% and a specificity of 94.1%.<\/p>\n<p><a href=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-28-100642.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-28-100642.png\" width=\"680\" height=\"392\" alt=\"\" class=\"wp-image-52896 aligncenter size-full\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-28-100642.png 680w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Screenshot-2025-03-28-100642-480x277.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 680px, 100vw\" \/><\/a><\/p>\n<p>Each Canhelp-UCa kit contains materials and reagents for 24 tests.<\/p>\n<p>&nbsp;<\/p>\n<h3>Procedure<\/h3>\n<p>The procedure for performing the Canhelp-UCa test involves the following steps:<\/p>\n<p><a href=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/UriBLAD-procedimento.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/UriBLAD-procedimento.png\" width=\"2480\" height=\"1190\" alt=\"\" class=\"wp-image-52899 aligncenter size-full\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/UriBLAD-procedimento.png 2480w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/UriBLAD-procedimento-1280x614.png 1280w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/UriBLAD-procedimento-980x470.png 980w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/UriBLAD-procedimento-480x230.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 2480px, 100vw\" \/><\/a><\/p>\n<h3>The Canhelp-UCa report\u00a0<\/h3>\n<p>The report provided by Canhelp-UCa includes a probability score based on the analysis of the expression of specific genetic markers in urine, providing useful information for the early diagnosis and monitoring of bladder cancer recurrence. Thanks to the integration with artificial intelligence software, the report provides timely assessments, supporting clinical decisions and helping to optimize patient management.<\/p>\n<p>If the probability score is:<\/p>\n<ul>\n<li>equal to or greater than 50: the result is to be considered positive<\/li>\n<li>less than 50: the result is to be considered negative<\/li>\n<\/ul>\n<p><a href=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Immagine3.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Immagine3-1024x253.png\" width=\"1024\" height=\"253\" alt=\"\" class=\"wp-image-52892 alignnone size-large\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Immagine3-980x242.png 980w, https:\/\/quimark.com\/wp-content\/uploads\/2025\/03\/Immagine3-480x119.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/a><\/p>\n<h3>Bibliography<\/h3>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33122139\/\" target=\"_blank\" rel=\"noopener\"><em>Wang, Q., Hu, L., Ma, W., Meng, Z., Li, P., Zhang, X., \u2026 &amp; Ye, D. (2021). UriBLAD: A urine-based gene expression assay for noninvasive detection of bladder cancer. The Journal of Molecular Diagnostics, 23(1), 61-70.<\/em><\/a><\/p>\n<p><a href=\"https:\/\/www.annalsofoncology.org\/article\/S0923-7534(23)04556-8\/fulltext\" target=\"_blank\" rel=\"noopener\"><em>Xu, H., Wang, S., Xue, D., Xu, Z., Zhang, Q., Wo, Q., \u2026 &amp; Ye, D. (2023). 214P Development and prospective validation of a multiplex RNA urine test for noninvasive detection and surveillance of urothelial carcinoma. Annals of Oncology, 34, S1559.<\/em><\/a><\/p>\n<p>&nbsp;<\/p>\n<h3>For more information click <a href=\"https:\/\/www.canhelpgenomics.com\/products_show?id=2\" target=\"_blank\" rel=\"noopener\">HERE<\/a><\/h3>\n<p><a href=\"https:\/\/www.canhelpgenomics.com\/products_show?id=2\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/quimark.com\/wp-content\/uploads\/2024\/07\/doctor-with-laptop-scaled.jpg\" width=\"2560\" height=\"1429\" alt=\"\" class=\"wp-image-52321 alignnone size-full\" srcset=\"https:\/\/quimark.com\/wp-content\/uploads\/2024\/07\/doctor-with-laptop-scaled.jpg 2560w, https:\/\/quimark.com\/wp-content\/uploads\/2024\/07\/doctor-with-laptop-1280x715.jpg 1280w, https:\/\/quimark.com\/wp-content\/uploads\/2024\/07\/doctor-with-laptop-980x547.jpg 980w, https:\/\/quimark.com\/wp-content\/uploads\/2024\/07\/doctor-with-laptop-480x268.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 2560px, 100vw\" \/><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 admin_label=\u201ds\u201d _builder_version=\u201d4.27.0\u2033 background_color=\u201d#002855\u2033 custom_margin=\u201d||-28px|||\u201d custom_padding=\u201d0px||36px||false|false\u201d box_shadow_style=\u201dpreset7\u2033 box_shadow_horizontal=\u201d0px\u201d box_shadow_vertical=\u201d100px\u201d box_shadow_color=\u201d#ffffff\u201d global_module=\u201d51463\u2033 saved_tabs=\u201dall\u201d global_colors_info=\u201d{}\u201d][et_pb_row column_structure=\u201d1_3,1_3,1_3\u2033 padding_top_bottom_link_1=\u201dtrue\u201d padding_left_right_link_1=\u201dtrue\u201d _builder_version=\u201d4.27.0\u2033 custom_padding=\u201d0px||0px||true\u201d animation_direction=\u201dbottom\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_3\u2033 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